Discussion The results of the current meta-analysis, that included 60,080 patients with T2DM, 14,804 of whom without established CV disease, demonstrate that GLP-1RA reduce the risk of MACE by 14% in the overall diabetic population, with an apparently greater effect in patients with known CV disease as compared with those without established CV disease (16% vs 6% reduction, respectively)
For example, individuals in the cohorts were older and mostly white men, thus hurting the results generalizability to the general population, while the researchers could not rule out residual confounding
Nature 337 , 184187 (1989)
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Spreading protein intake across meals often feels more manageable than trying to concentrate it all at once